rs1057519887
|
|
AA |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs1057519887
|
|
AT |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs121913433
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma.
|
20415598 |
2010 |
rs121913433
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: molecular bases for EGFR-targeted therapy.
|
21531084 |
2011 |
rs121913433
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs149840192
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs149840192
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs769696078
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs2227983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The EGFR-R497K polymorphism is a potential predictor for overall survival in HNSCC patients treated with cetuximab based therapy in the palliative setting.
|
22287728 |
2012 |
rs2227983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This pilot study provides preliminary evidence supporting genetic variation of EGFR (rs2227983), KRAS (rs61764370) and FCGR2A (rs180127) as useful biomarkers for predicting reduced skin toxicity in HNSCC patients treated with a cetuximab-based therapy.
|
27938998 |
2016 |
rs1057519830
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The occurrence of the P546S mutation needs to be evaluated in HNSCC, as a well as a prospective evaluation of cetuximab anti-tumour activity in patients with tumours harbouring the mutation.
|
23578570 |
2013 |
rs1057519847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one of the patients with an EGFR mutation in the primary HNSCC carried the same mutation (L858R) in the lymph node metastasis.
|
21953075 |
2012 |
rs1057519848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one of the patients with an EGFR mutation in the primary HNSCC carried the same mutation (L858R) in the lymph node metastasis.
|
21953075 |
2012 |
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one of the patients with an EGFR mutation in the primary HNSCC carried the same mutation (L858R) in the lymph node metastasis.
|
21953075 |
2012 |
rs121434569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher frequency of EGFR-TK domain mutations together with the presence of the T790M mutation suggests that identification of these mutations might streamline the therapy and provide a better prognosis in HNSCC cases.
|
28352186 |
2017 |
rs1256743514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutational analysis in the eight HNSCC cell lines revealed an <i>EGFR</i> mutation (p.H773Y) and gene amplification in the HN13 cells.
|
28881811 |
2017 |
rs1276184054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study.
|
19726454 |
2009 |
rs1389500636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The HNSCC cells with MAPK1 E322K exhibited enhanced EGFR phosphorylation and erlotinib sensitivity compared with wild-type MAPK1 cells.
|
26181029 |
2015 |
rs2072454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
EGFR intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05).
|
25511740 |
2015 |
rs6970262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users.
|
25511740 |
2015 |
rs754426793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification of the rare EGFR mutation p.G796S as somatic and germline mutation in white patients with squamous cell carcinoma of the head and neck.
|
18528899 |
2008 |
rs776375114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four novel mutations (E709K, V765G, Ins770G, and G1022S) and one mutation well-known in lung cancer (L858R) were identified in six HNSCC samples (7%), but we could not find any mutations in the extracellular domain of EGFR, such as EGFRvIII, in this study.
|
19726454 |
2009 |
rs845561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users.
|
25511740 |
2015 |